Aseptic Connections – Choosing your sterile tubing connection

When it comes to connecting tubing to tanks, single-use bags or manifolds, there are many different options each offering their own benefits. But as we covered in our previous blog, the start point, is to focus on the process itself, not the array of different solutions. Today, we’ll be looking at some of the best aseptic connection options and helping you to evaluate which is the best fit for your process.

The simplest form of connecting is using a Quick Connector such as the MPC or MPX from Colder CPC. Whilst this offers a quick, simple and reliable connection much more secure than a Luer style connector, the connection still needs to be made in an isolator to maintain sterility.


If you don’t have the benefit of a clean room or isolator, sterile connections can still be made using sterile connectors or weld machines.


Sterile Connectors

There is a wide choice of connectors available in the market, with an array of different methods of connection. The biggest difference between these connectors is whether they are Genderless or Gendered.


Gendered connectors can be beneficial when two connections need to be made but it’s important that they are not cross connected, using a male on one tube and female on the other ensures the lines are connected correctly – helping to reduce human error.  A gendered connector  requires the end user to ensure that the opposing male and female options are specified on the two parts being connected, this can sometimes get confusing when products are being shipped from multiple sites. This confusion is avoided by using Genderless connectors.

Genderless Aseptic connectors are a desired option to reduce the number of stock items required.

Another real benefit of gendered or genderless connectors, is the ability to connect different sized tubing with a single size of coupling, something that cannot be achieved with a tube welder.


Tube Welding

When welding tubing the most restrictive elements are the type of tubing (TPE), accessibility to the tubing where the connection needs to be made and the ability to only weld the same sized tubing together.
In the right circumstances, the welder can be an excellent option – e.g. making multiple connections to a bag line for samples, harvesting and additions. But crucially, in order for the welder to be a viable option the tubing must be a TPE product, as platinum cured silicone can not be welded.
Using tube welders such as the Vante Tube Welder, which is a standalone automated benchtop system, connections can be made that haven’t been planned for. Perfect for when the unexpected happens in a process and you need to make an unplanned connection of a bag or bottle into your system for additions, sampling or harvesting.

Which aseptic connection is right for you?

Do you need to discuss in more detail? We are available to discuss your connection and disconnection options at your site and our focus is always to offer you the best solution for your process. Other manufacturers solutions are available for connecting and disconnecting tubing and BioPharma Dynamics offer an open architecture on our assemblies, if other connectors are already validated into your process.
BioPharma Dynamics are approved distributors for Colder CPC connections and Vante tube welders and sealers in the UK.

3 thoughts on “Aseptic Connections – Choosing your sterile tubing connection

  1. Dear Sir/ Madam,
    Hope you are well.
    Do you have any distributor in Bahrain?
    We are medical group consists of pharmacy, hospital, medical distribution, Bariatric surgery supplements, etc. Our medical distribution division is participating in tenders in Bahrain market. Currently we have a requirement for Sterile tube welder. Please revert back to us to forward our enquiry.
    Looking forward to hear from you soon.

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